Georg Hess Selected Research

temsirolimus

6/2020	Final Results of a Phase I/II Trial of the Combination Bendamustine and Rituximab With Temsirolimus (BeRT) in Relapsed Mantle Cell Lymphoma and Follicular Lymphoma.
1/2018	Comparison of two doses of intravenous temsirolimus in patients with relapsed/refractory mantle cell lymphoma.
12/2017	Health-related quality of life data from a phase 3, international, randomized, open-label, multicenter study in patients with previously treated mantle cell lymphoma treated with ibrutinib versus temsirolimus.
2/2016	Ibrutinib versus temsirolimus in patients with relapsed or refractory mantle-cell lymphoma: an international, randomised, open-label, phase 3 study.
1/2015	Effect of prognostic classification on temsirolimus efficacy and safety in patients with relapsed or refractory mantle cell lymphoma: a retrospective analysis.
6/2013	A phase I/II trial to evaluate the safety, feasibility and activity of salvage therapy consisting of the mTOR inhibitor Temsirolimus added to standard therapy of Rituximab and DHAP for the treatment of patients with relapsed or refractory diffuse large cell B-Cell lymphoma - the STORM trial.
1/2012	Relapsed and/or Refractory Mantle Cell Lymphoma: What Role for Temsirolimus?
12/2009	Temsirolimus for the treatment of mantle cell lymphoma.
12/2009	Temsirolimus in mantle cell lymphoma and other non-Hodgkin lymphoma subtypes.
8/2009	Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma.

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Georg Hess Research Topics

Disease

22	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 05/2022 - 07/2007
14	Neoplasms (Cancer) 08/2022 - 02/2007
11	Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular) 04/2022 - 11/2004
11	Lymphoma (Lymphomas) 01/2022 - 07/2007
10	Non-Hodgkin Lymphoma (Lymphosarcoma) 08/2020 - 11/2004
7	Heart Failure 12/2017 - 01/2005
6	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 01/2022 - 07/2007
5	B-Cell Lymphoma (Lymphoma, B Cell) 01/2021 - 10/2008
5	Infections 07/2015 - 02/2003
4	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 10/2018 - 06/2011
4	Liver Diseases (Liver Disease) 01/2017 - 09/2006
4	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 03/2008 - 04/2003
3	Multiple Myeloma 11/2019 - 01/2015
3	Fibrosis (Cirrhosis) 01/2017 - 09/2008
3	Viremia 12/2006 - 03/2004
2	Residual Neoplasm 04/2022 - 10/2005
2	Liver Cirrhosis (Hepatic Cirrhosis) 01/2017 - 09/2008
2	Philadelphia Chromosome 04/2016 - 09/2003
2	Bites and Stings (Sting) 04/2016 - 03/2016
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 04/2016 - 04/2003
2	Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral) 08/2015 - 03/2010
2	Genetic Translocation (Chromosomal Translocation) 04/2013 - 12/2011
2	Left Ventricular Dysfunction 07/2011 - 09/2008
2	Systolic Heart Failure 07/2011 - 07/2011
2	Myocardial Infarction 03/2011 - 04/2010
2	Acute Coronary Syndrome 03/2011 - 04/2010
2	Thrombocytopenia (Thrombopenia) 12/2009 - 08/2009
2	Anemia 12/2009 - 08/2009
2	Asthenia 12/2009 - 08/2009
2	Neutropenia 12/2009 - 08/2009
2	Graft vs Host Disease (Graft-Versus-Host Disease) 06/2008 - 01/2007
2	Castleman Disease (Castleman's Disease) 03/2007 - 09/2006
2	Leukemia 05/2004 - 09/2003
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 05/2004 - 04/2003
1	Cognitive Dysfunction 01/2022
1	Enterovirus Infections 08/2020
1	Diarrhea 10/2018
1	Atrial Fibrillation 10/2018
1	Hypertension (High Blood Pressure) 10/2018
1	Neoplasm Metastasis (Metastasis) 06/2017

Drug/Important Bio-Agent (IBA)

15	Rituximab (Mabthera)FDA Link 01/2021 - 11/2006
10	temsirolimus FDA Link 06/2020 - 08/2009
9	ibrutinibIBA 05/2022 - 02/2016
7	pro-brain natriuretic peptide (1-76)IBA 12/2017 - 01/2005
7	Brain Natriuretic Peptide (Natrecor)FDA Link 12/2017 - 01/2005
7	Cyclophosphamide (Cytoxan)FDA LinkGeneric 11/2017 - 03/2010
5	Imatinib Mesylate (Gleevec)FDA Link 03/2008 - 04/2003
4	Biological ProductsIBA 01/2022 - 08/2011
4	blinatumomabIBA 11/2020 - 08/2008
4	Biomarkers (Surrogate Marker)IBA 01/2017 - 05/2011
4	fludarabineIBA 01/2017 - 03/2010
4	Troponin T (Troponin T1)IBA 08/2011 - 04/2010
3	Bendamustine Hydrochloride FDA Link 01/2021 - 07/2007
3	Bortezomib (Velcade)FDA Link 11/2017 - 09/2006
3	ofatumumab FDA Link 01/2017 - 06/2011
3	TOR Serine-Threonine KinasesIBA 01/2015 - 08/2009
3	Monoclonal AntibodiesIBA 05/2012 - 10/2008
3	Doxorubicin (Adriamycin)FDA LinkGeneric 05/2012 - 03/2010
3	Proteins (Proteins, Gene)FDA Link 10/2008 - 02/2003
3	AntibodiesIBA 12/2006 - 02/2003
3	ImmunosorbentsIBA 08/2006 - 03/2004
3	EnzymesIBA 08/2006 - 03/2004
3	RNA (Ribonucleic Acid)IBA 05/2005 - 02/2003
2	tafasitamabIBA 01/2022 - 01/2022
2	Agammaglobulinaemia Tyrosine KinaseIBA 01/2022 - 10/2018
2	pixantrone (BBR 2778)IBA 01/2022 - 04/2011
2	Immunoconjugates (Immunoconjugate)IBA 01/2021 - 02/2013
2	Methotrexate (Mexate)FDA LinkGeneric 11/2017 - 05/2016
2	Cytarabine (Cytosar-U)FDA LinkGeneric 11/2017 - 05/2016
2	Thiotepa (Triethylenethiophosphoramide)FDA LinkGeneric 11/2017 - 05/2016
2	Dexamethasone (Maxidex)FDA LinkGeneric 11/2017 - 01/2015
2	Cyclin D1IBA 04/2013 - 12/2011
2	Vincristine (Oncovin)FDA LinkGeneric 05/2012 - 04/2011
2	Prednisone (Sone)FDA LinkGeneric 05/2012 - 04/2011
2	TroponinIBA 08/2011 - 04/2010
2	Fatty Acid Binding Protein 3IBA 07/2011 - 03/2011
2	CytokinesIBA 07/2011 - 09/2006
2	Fatty Acid-Binding ProteinsIBA 05/2011 - 03/2011
2	Alemtuzumab (Campath)FDA Link 03/2010 - 01/2007
2	Natriuretic PeptidesIBA 05/2009 - 01/2005
1	obinutuzumabIBA 01/2022
1	brexucabtagene autoleucelIBA 01/2022
1	Lenalidomide (CC 5013)FDA Link 01/2022
1	abemaciclibIBA 01/2021
1	polatuzumab vedotinIBA 01/2021
1	ORALIT (ORS)IBA 01/2017

Therapy/Procedure

25	Therapeutics 01/2022 - 11/2004
11	Stem Cell Transplantation 11/2019 - 09/2003
7	Drug Therapy (Chemotherapy) 08/2022 - 04/2003
3	Salvage Therapy 01/2022 - 06/2013
3	Radiotherapy 11/2017 - 05/2013
2	Aftercare (After-Treatment) 04/2022 - 10/2005
2	Transplantation 01/2018 - 09/2013
2	Oral Surgery (Maxillofacial Surgery) 06/2017 - 01/2015
2	Immunotherapy 08/2008 - 07/2007
2	Hematopoietic Stem Cell Transplantation 01/2007 - 09/2003
1	Radioimmunotherapy 04/2022
1	Complementary Therapies (Alternative Medicine) 07/2021
1	Homologous Transplantation 11/2019
1	Combination Drug Therapy (Combination Chemotherapy) 01/2018